4GVM
HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Gag-Pol polyprotein | polymer | 163 | 17942.5 | 1 | UniProt (P12497) Pfam (PF00665) In PDB | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1) | Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, PR, Retropepsin, Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT, p51 RT, p15, Integrase, IN |
| 2 | A | ARSENIC | non-polymer | 74.9 | 2 | Chemie (ARS) | |||
| 3 | A | (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](tert-butoxy)ethanoic acid | non-polymer | 462.8 | 1 | Chemie (LF2) | |||
| 4 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Thr 128 | Ala 1275 | engineered mutation |
| Lys 185 | Phe 1332 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17942.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 612.6 | |
| All* | Total formula weight | 18555.1 |
