4GUR

Crystal structure of LSD2-NPAC with H3 in space group P21

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lysine-specific histone demethylase 1B	polymer	776	87051.5	1	UniProt (Q8NB78) Pfam (PF07496) Pfam (PF04433) Pfam (PF01593) In PDB	Homo sapiens (human)	LSD2, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2
2	B	Putative oxidoreductase GLYR1	polymer	124	13528.3	1	UniProt (Q49A26) In PDB	Homo sapiens (human)	NPAC, 3-hydroxyisobutyrate dehydrogenase-like protein, Cytokine-like nuclear factor N-PAC, Glyoxylate reductase 1 homolog, Nuclear protein NP60, Nuclear protein of 60 kDa
3	C	Histone H3.3	polymer	21	2263.7	1	UniProt (P84243) In PDB	Homo sapiens	H3
4	A	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	1	Chemie (FAD)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	A	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
7		water	water		18.0	98	Chemie (HOH)

Sequence modifications

A: 51 - 822 (UniProt: Q8NB78)

PDB	External Database	Details
Pro 47	-	expression tag
Leu 48	-	expression tag
Gly 49	-	expression tag
Ser 50	-	expression tag

B: 152 - 268 (UniProt: Q49A26)

PDB	External Database	Details
Pro 145	-	expression tag
Leu 146	-	expression tag
Gly 147	-	expression tag
Ser 148	-	expression tag
Pro 149	-	expression tag
Glu 150	-	expression tag
Phe 151	-	expression tag

C: 1 - 21 (UniProt: P84243)

PDB	External Database	Details
Met 4	Lys 5	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102843.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1073.9
All*	Total formula weight	103917.4

*Water molecules are not included.