4GU6
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-N-methyl-methanesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Focal adhesion kinase 1 | polymer | 282 | 32304.2 | 2 | UniProt (Q05397) Pfam (PF07714) In PDB | Homo sapiens (human) | FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK |
| 2 | A, B | N-(3-{[(5-cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide | non-polymer | 432.5 | 2 | Chemie (10N) | |||
| 3 | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
A, B: 411 - 689 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64608.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 865.0 | |
| All* | Total formula weight | 65473.4 |
