4GTX

Crystal structure of mouse Enpp1 in complex with TMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I	polymer	823	94560.2	2	UniProt (Q9R1E6) UniProt (G3X9S2) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) UniProt (by SIFTS) (P06802)	Mus musculus (E)	E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD, Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d
2	C (C)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
3	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	E, F, K, L (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	G, M (A, B)	THYMIDINE-5'-PHOSPHATE	non-polymer		322.2	2	Chemie (TMP) PubChem (18531120) PubChem (20711568) PubChem (1139) PubChem (23657880) PubChem (24802545) PubChem (44361457) PubChem (25113134) PubChem (51397487) PubChem (444919) PubChem (9700) PubChem (5274091) PubChem (5748250) PubChem (10147784) PubChem (129069890) PubChem (133126478) PubChem (164603144)
6	H, I, N, O (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
7	J, P (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)

Sequence modifications

A, B: 51 - 59 (UniProt: Q9R1E6)

PDB	External Database	Details
Arg 59	Lys 59	engineered mutation

A, B: 92 - 905 (UniProt: G3X9S2)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	189120.4
Branched	Number of molecules	2
	Total formula weight	1497.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1871.0
All*	Total formula weight	192488.8

*Water molecules are not included.