4GT9

T. Maritima FDTS with FAD, dUMP and Folate.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Thymidylate synthase thyX	polymer	232	27503.7	1	UniProt (Q9WYT0) Pfam (PF02511)	Thermotoga maritima	TS, TSase
2	B (A)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	1	Chemie (FAD)
3	C (A)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	1	Chemie (UMP) PubChem (688) PubChem (65063) PubChem (57164254) PubChem (446899) PubChem (446900) PubChem (71773959) PubChem (92144438) PubChem (92209480) PubChem (92209481) PubChem (92209482) PubChem (92449733) PubChem (133126534)
4	D, E (A)	N-({4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]phenyl}carbonyl)-L-glutamic acid	non-polymer		457.4	2	Chemie (MEF) PubChem (135398645) PubChem (135400185) PubChem (135398652) PubChem (135402041) PubChem (135475957) PubChem (135515584) PubChem (135564585) PubChem (136035413) PubChem (137054706)
5	F (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG) PubChem (8117)
6	G (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL) PubChem (312)
7	H (A)	water	water		18.0	208	Chemie (HOH)

Sequence modifications

A: 1 - 220 (UniProt: Q9WYT0)

PDB	External Database	Details
Met -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27503.7
Non-Polymers*	Number of molecules	6
	Total formula weight	2150.2
All*	Total formula weight	29653.9

*Water molecules are not included.