4GT7
An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, non-receptor binding conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Ig epsilon chain C region | polymer | 221 | 24719.9 | 4 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | E, F, G (E, F, G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 3 | H (H) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 329 - 545 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 325 | - | expression tag |
| Asp 326 | - | expression tag |
| Pro 327 | - | expression tag |
| Ala 328 | - | expression tag |
| Cys 335 | Gly 216 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98879.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3481.2 | |
| All* | Total formula weight | 102360.7 |
