4GS0
Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein phosphatase non-receptor type 6 | polymer | 308 | 35386.9 | 2 | UniProt (P29350) Pfam (PF00102) In PDB | Homo sapiens (human) | Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1 |
2 | C | Tyrosine-protein kinase JAK1 | polymer | 4 | 550.5 | 1 | UniProt (P23458) In PDB | Homo sapiens | Janus kinase 1, JAK-1 |
3 | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B: 243 - 528 (UniProt: P29350)
C: 1 - 4 (UniProt: P23458)
PDB | External Database | Details |
---|---|---|
Met 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
His 225 | - | expression tag |
His 226 | - | expression tag |
His 227 | - | expression tag |
Gly 228 | - | expression tag |
Ser 229 | - | expression tag |
Leu 230 | - | expression tag |
Val 231 | - | expression tag |
Pro 232 | - | expression tag |
Arg 233 | - | expression tag |
Ser 234 | - | expression tag |
Glu 235 | - | expression tag |
Asn 236 | - | expression tag |
Leu 237 | - | expression tag |
Tyr 238 | - | expression tag |
Phe 239 | - | expression tag |
Gln 240 | - | expression tag |
Gly 241 | - | expression tag |
Ser 242 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Unk 1 | Glu 1033 | SEE REMARK 999 |
Unk 2 | Tyr 1034 | SEE REMARK 999 |
Unk 4 | Thr 1036 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 71324.3 | |
All* | Total formula weight | 71324.3 |