4GS0

Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 6	polymer	308	35386.9	2	UniProt (P29350) Pfam (PF00102)	Homo sapiens (human)	Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1
2	C (C)	Tyrosine-protein kinase JAK1	polymer	4	550.5	1	UniProt (P23458)	Homo sapiens	Janus kinase 1, JAK-1
3	D, E (A, B)	water	water		18.0	287	Chemie (HOH)

Sequence modifications

A, B: 243 - 528 (UniProt: P29350)

PDB	External Database	Details
Met 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
Gly 228	-	expression tag
Ser 229	-	expression tag
Leu 230	-	expression tag
Val 231	-	expression tag
Pro 232	-	expression tag
Arg 233	-	expression tag
Ser 234	-	expression tag
Glu 235	-	expression tag
Asn 236	-	expression tag
Leu 237	-	expression tag
Tyr 238	-	expression tag
Phe 239	-	expression tag
Gln 240	-	expression tag
Gly 241	-	expression tag
Ser 242	-	expression tag

C: 1 - 4 (UniProt: P23458)

PDB	External Database	Details
Unk 1	Glu 1033	SEE REMARK 999
Unk 2	Tyr 1034	SEE REMARK 999
Unk 4	Thr 1036	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	71324.3
All*	Total formula weight	71324.3

*Water molecules are not included.