4GRG

Crystal structure of IgE complexed with E2_79, an anti-IgE inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	ANTI-IGE INHIBITOR E2_79	polymer	135	14647.3	2		Escherichia coli
2	C, D (C, D)	Ig epsilon chain C region	polymer	230	25637.8	2	UniProt (P01854) Pfam (PF07654)	Homo sapiens (human)

Sequence modifications

C, D: 329 - 547 (UniProt: P01854)

PDB	External Database	Details
Ala 325	-	expression tag
Asp 326	-	expression tag
Pro 327	-	expression tag
Ala 328	-	expression tag
Cys 335	Gly 216	engineered mutation
Ala 548	-	expression tag
Ala 549	-	expression tag
Asp 550	-	expression tag
Asp 551	-	expression tag
Asp 552	-	expression tag
Asp 553	-	expression tag
Lys 554	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80570.3
All*	Total formula weight	80570.3

*Water molecules are not included.