4GO0

Crystal structure of the c707s mutant of c-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with NADPH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Cytosolic 10-formyltetrahydrofolate dehydrogenase	polymer	517	56605.5	4	UniProt (P28037) Pfam (PF00171)	Rattus norvegicus (brown rat rat rats)	10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, FBP-CI
2	E, F, G, H (A, B, C, D)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)

Sequence modifications

A, B, C, D: 397 - 902 (UniProt: P28037)

PDB	External Database	Details
Met 386	-	expression tag
Arg 387	-	expression tag
Gly 388	-	expression tag
Ser 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
Thr 395	-	expression tag
Thr 396	-	expression tag
Ser 707	Cys 707	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	226421.9
Non-Polymers*	Number of molecules	4
	Total formula weight	2981.7
All*	Total formula weight	229403.6

*Water molecules are not included.