4GNZ
Crystal structure of the c707s mutant of c-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with NADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytosolic 10-formyltetrahydrofolate dehydrogenase | polymer | 517 | 56605.5 | 4 | UniProt (P28037) Pfam (PF00171) | Rattus norvegicus (brown rat rat rats) | 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, FBP-CI |
| 2 | E, GA, Q, Y (A, D, B, C) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 3 | AA, BA, CA, DA, EA... (C, A, D, B) | SULFATE ION | non-polymer | 96.1 | 28 | Chemie (SO4) | |||
| 4 | FA, NA, P, X (C, D, A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 5 | OA, PA, QA, RA (A, B, C, D) | water | water | 18.0 | 1056 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 397 - 902 (UniProt: P28037)
| PDB | External Database | Details |
|---|---|---|
| Met 386 | - | expression tag |
| Arg 387 | - | expression tag |
| Gly 388 | - | expression tag |
| Ser 389 | - | expression tag |
| His 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| Thr 395 | - | expression tag |
| Thr 396 | - | expression tag |
| Ser 707 | Cys 707 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 226421.9 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 6031.8 | |
| All* | Total formula weight | 232453.7 |
