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4GG9

tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Queuine tRNA-ribosyltransferasepolymer38642925.71UniProt (P28720)
Pfam (PF01702)
Zymomonas mobilis subsp. mobilisGuanine insertion enzyme, tRNA-guanine transglycosylase
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C, D
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
4E
(A)
4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(thiophen-2-ylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-onenon-polymer436.61Chemie (0WW)
5F
(A)
waterwater18.0303Chemie (HOH)
Sequence modifications
A: 1 - 386 (UniProt: P28720)
PDBExternal DatabaseDetails
Lys 312Thr 312engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight42925.7
Non-Polymers*Number of molecules4
Total formula weight686.2
All*Total formula weight43611.9
*Water molecules are not included.

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PDB entries from 2025-07-30

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