4GDK

Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Ubiquitin-like protein ATG12	polymer	91	10282.0	2	UniProt (O94817) Pfam (PF04110) In PDB	Homo sapiens (human)	Autophagy-related protein 12, APG12-like
2	B, E	Autophagy protein 5	polymer	275	32489.2	2	UniProt (Q9H1Y0) Pfam (PF20638) Pfam (PF20637) Pfam (PF04106) In PDB	Homo sapiens (human)	APG5-like, Apoptosis-specific protein
3	C, F	Autophagy-related protein 16-1	polymer	36	4657.4	2	UniProt (Q676U5) In PDB	Homo sapiens (human)	APG16-like 1
4	B, E	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5		water	water		18.0	76	Chemie (HOH)

Sequence modifications

A, D: 52 - 140 (UniProt: O94817)

PDB	External Database	Details
Gly 50	-	EXPRESSION TAG
Ser 51	-	EXPRESSION TAG

C, F: 11 - 43 (UniProt: Q676U5)

PDB	External Database	Details
Ser 8	-	EXPRESSION TAG
His 9	-	EXPRESSION TAG
Met 10	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	94857.3
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	94903.3

*Water molecules are not included.