4G9R

B-Raf V600E Kinase Domain Bound to a Type II Dihydroquinazoline Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein kinase B-raf	polymer	307	35247.6	2	UniProt (P15056) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
2	A, B	3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide	non-polymer		451.5	2	Chemie (B1E)

Sequence modifications

A, B: 432 - 726 (UniProt: P15056)

PDB	External Database	Details
Met 420	-	expression tag
Asp 421	-	expression tag
Arg 422	-	expression tag
Gly 423	-	expression tag
Ser 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
Gly 431	-	expression tag
Glu 600	Val 600	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70495.2
Non-Polymers*	Number of molecules	2
	Total formula weight	903.0
All*	Total formula weight	71398.3

*Water molecules are not included.