4G8Z
pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Dihydrofolate reductase | polymer | 204 | 23380.9 | 1 | UniProt (P16184) | Pneumocystis jirovecii | |
| 2 | B (X) | TRIMETHOPRIM | non-polymer | 290.3 | 1 | Chemie (TOP) | |||
| 3 | C (X) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 4 | D (X) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
X: 3 - 206 (UniProt: P16184)
| PDB | External Database | Details |
|---|---|---|
| Ser 37 | Lys 37 | engineered mutation |
| Asn 69 | Phe 69 | engineered mutation |
| Ala 84 | Glu 84 | conflict |
| Ala 85 | Ser 85 | conflict |
| Ala 86 | Leu 86 | conflict |
| Ala 87 | Asp 87 | conflict |
| Ala 88 | Leu 88 | conflict |
| Ala 89 | Gly 89 | conflict |
| Ala 90 | Asn 90 | conflict |
| Ala 91 | Gly 91 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23380.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1035.7 | |
| All* | Total formula weight | 24416.6 |
