4G5P
Crystal structure of EGFR kinase T790M in complex with BIBW2992
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Epidermal growth factor receptor | polymer | 330 | 37609.5 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
2 | A | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | non-polymer | 488.0 | 1 | Chemie (0WN) | |||
3 | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 693 | - | EXPRESSION TAG |
Ser 694 | - | EXPRESSION TAG |
Met 695 | - | EXPRESSION TAG |
Met 790 | Thr 790 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75219.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 488.0 | |
All* | Total formula weight | 75707.0 |