4G3G

Crystal structure of murine NF-kappaB inducing kinase (NIK) V408L bound to a 2-(aminothiazolyl)phenol (cmp3)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	NF-kappa-beta-inducing kinase	polymer	350	38805.6	1	UniProt (Q9WUL6) Pfam (PF00069)	Mus musculus (mouse)	Serine/threonine-protein kinase NIK
2	B (A)	4-fluoro-2-{[4-(pyridin-4-yl)-1,3-thiazol-2-yl]amino}phenol	non-polymer		287.3	1	Chemie (0WA)
3	C (A)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A: 345 - 675 (UniProt: Q9WUL6)

PDB	External Database	Details
Met 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
Gly 336	-	expression tag
Glu 337	-	expression tag
Asn 338	-	expression tag
Leu 339	-	expression tag
Tyr 340	-	expression tag
Phe 341	-	expression tag
Gln 342	-	expression tag
Gly 343	-	expression tag
Ser 344	-	expression tag
Leu 408	Val 408	engineered mutation
Gly 676	-	expression tag
Asn 677	-	expression tag
Ser 678	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38805.6
Non-Polymers*	Number of molecules	1
	Total formula weight	287.3
All*	Total formula weight	39092.9

*Water molecules are not included.