4G31
Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Eukaryotic translation initiation factor 2-alpha kinase 3 | polymer | 299 | 34797.2 | 1 | UniProt (Q9NZJ5) Pfam (PF00069) In PDB | Homo sapiens (human) | PKR-like endoplasmic reticulum kinase, PERK, Pancreatic eIF2-alpha kinase, HsPEK |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | A | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone | non-polymer | 451.4 | 1 | Chemie (0WH) | |||
| 4 | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 587 - 659 (UniProt: Q9NZJ5)
A: 868 - 1092 (UniProt: Q9NZJ5)
| PDB | External Database | Details |
|---|---|---|
| Gly 586 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34797.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 543.5 | |
| All* | Total formula weight | 35340.8 |
