4G2W
Crystal structure of PDE5A in complex with its inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 347 | 40091.1 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (human) | cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE |
| 2 | B (A) | 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | non-polymer | 448.6 | 1 | Chemie (NI0) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (A) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 535 - 860 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Met 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Ser 516 | - | expression tag |
| Ser 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
| His 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Ser 525 | - | expression tag |
| Gly 526 | - | expression tag |
| Leu 527 | - | expression tag |
| Val 528 | - | expression tag |
| Pro 529 | - | expression tag |
| Arg 530 | - | expression tag |
| Gly 531 | - | expression tag |
| Ser 532 | - | expression tag |
| His 533 | - | expression tag |
| Met 534 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40091.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 644.4 | |
| All* | Total formula weight | 40735.5 |
