4G09
The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histidinol dehydrogenase | polymer | 438 | 47180.3 | 1 | UniProt (Q8G2R2) Pfam (PF00815) | Brucella suis | HDH |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | F (A) | (3S)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one | non-polymer | 335.4 | 1 | Chemie (0VD) | |||
| 6 | G (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 1 - 430 (UniProt: Q8G2R2)
| PDB | External Database | Details |
|---|---|---|
| Ser 366 | Cys 366 | engineered mutation |
| Leu 431 | - | expression tag |
| Glu 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
| His 437 | - | expression tag |
| His 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47180.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 636.4 | |
| All* | Total formula weight | 47816.7 |
