4FXO

Zinc-mediated allosteric inhibiton of caspase-6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Caspase-6	polymer	299	34187.9	4	UniProt (P55212) Pfam (PF00656)	Homo sapiens (human)	CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11
2	E, F, G, H (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	I, J, K, L (A, B, C, D)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 293 (UniProt: P55212)

PDB	External Database	Details
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	136751.5
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	137013.2

*Water molecules are not included.