4FX7

Structure of Sym2 D9V+D55V+D130V+D176V

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Imidazole glycerol phosphate synthase subunit HisF	polymer	251	27252.4	4	UniProt (Q9X0C6) Pfam (PF00977)	Thermotoga maritima	IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF
2	E, F, G, H, I... (A, B, C, D)	HYDROGENPHOSPHATE ION	non-polymer		96.0	8	Chemie (PI)
3	M, N, O, P (A, B, C, D)	water	water		18.0	348	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 98 (UniProt: Q9X0C6)

PDB	External Database	Details
Met 1	-	expression tag
Arg 3	Ala 124	engineered mutation
Val 9	Asp 130	engineered mutation
His 22	Tyr 143	engineered mutation
Val 55	Asp 176	engineered mutation
Leu 244	-	expression tag
Glu 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag

A, B, C, D: 99 - 219 (UniProt: Q9X0C6)

PDB	External Database	Details
Val 130	Asp 130	engineered mutation
His 143	Tyr 143	engineered mutation
Val 176	Asp 176	engineered mutation

A, B, C, D: 220 - 243 (UniProt: Q9X0C6)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109009.7
Non-Polymers*	Number of molecules	8
	Total formula weight	767.8
All*	Total formula weight	109777.5

*Water molecules are not included.