4FWW
Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage-stimulating protein receptor | polymer | 527 | 56132.5 | 1 | UniProt (Q04912) Pfam (PF01403) Pfam (PF01437) | Homo sapiens (human) | MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain |
| 2 | B (B) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G31886NL) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G, H, I (A) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 5 | J, K, L, M (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | N, O, P, Q (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 7 | R (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | S (A) | water | water | 18.0 | 358 | Chemie (HOH) |
Sequence modifications
A: 42 - 568 (UniProt: Q04912)
| PDB | External Database | Details |
|---|---|---|
| Leu 306 | Arg 306 | conflict |
| Val 307 | Arg 307 | conflict |
| Pro 308 | Arg 308 | conflict |
| Ser 311 | Ala 311 | conflict |
| Gln 322 | Arg 322 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56132.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 748.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1210.1 | |
| All* | Total formula weight | 58091.3 |
