4FW7
Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | polymer | 302 | 33418.9 | 4 | UniProt (P47205) Pfam (PF03331) | Pseudomonas aeruginosa | Protein envA, UDP-3-O-acyl-GlcNAc deacetylase |
| 2 | E, FA, N, X (A, D, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, GA, O, Y (A, D, B, C) | N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]biphenyl-4-carboxamide | non-polymer | 314.3 | 4 | Chemie (L63) | |||
| 4 | AA, BA, CA, DA, G... (C, A, D, B) | GLYCEROL | non-polymer | 92.1 | 17 | Chemie (GOL) | |||
| 5 | EA, JA, K, L, M... (C, D, A, B) | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 6 | KA, LA, MA, NA (A, B, C, D) | water | water | 18.0 | 731 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 299 (UniProt: P47205)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 40 | Cys 40 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 133675.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 3497.9 | |
| All* | Total formula weight | 137173.4 |
