4FW5
Crystal Structure of the LpxC in complex with 4'-BROMO-N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | polymer | 302 | 33418.9 | 4 | UniProt (P47205) Pfam (PF03331) | Pseudomonas aeruginosa | Protein envA, UDP-3-O-acyl-GlcNAc deacetylase |
| 2 | E, I, O, S (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, J, P, T (A, B, C, D) | 4'-bromo-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]biphenyl-4-carboxamide | non-polymer | 393.2 | 4 | Chemie (L58) | |||
| 4 | G, K, L, M, Q (A, B, C) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 5 | H, N, R, U (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 571 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 299 (UniProt: P47205)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 40 | Cys 40 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 133675.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2498.2 | |
| All* | Total formula weight | 136173.7 |
