4FVU
Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nucleoprotein | polymer | 243 | 27212.1 | 1 | UniProt (P13699) Pfam (PF17290) | Lassa virus Josiah (LASV) | Nucleocapsid protein, Protein N |
| 2 | B (B) | RNA (5'-R(*GP*GP*AP*GP*GP*GP*AP*G)-3') | polymer | 8 | 2684.7 | 1 | SYNTHETIC CONSTRUCT | ||
| 3 | C (C) | RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3') | polymer | 8 | 2398.5 | 1 | SYNTHETIC CONSTRUCT | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 342 - 569 (UniProt: P13699)
| PDB | External Database | Details |
|---|---|---|
| Met 327 | - | expression tag |
| Ala 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| Val 335 | - | expression tag |
| Asp 336 | - | expression tag |
| Asp 337 | - | expression tag |
| Asp 338 | - | expression tag |
| Asp 339 | - | expression tag |
| Arg 340 | - | expression tag |
| Met 341 | - | expression tag |
| Ala 391 | Glu 390 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 32295.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 89.7 | |
| All* | Total formula weight | 32384.9 |
