4FUI
Crystal Structure of the Urokinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 246 | 27715.6 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
| 2 | B (A) | 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE | non-polymer | 344.4 | 1 | Chemie (UI3) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | K (A) | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
| 7 | L (A) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A: 1 - 246 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 121 | Cys 299 | ENGINEERED MUTATION |
| Gln 144 | Asn 322 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27715.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1142.0 | |
| All* | Total formula weight | 28857.6 |
