4FRB

Crystal Structure of ABBA+UDP+Gal at pH 8.0 with MPD as the cryoprotectant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histo-blood group ABO system transferase	polymer	294	34371.7	1	UniProt (H6A2X0) Pfam (PF03414) UniProt (by SIFTS) (P16442)	Homo sapiens (human)	Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
2	B (A)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	1	Chemie (UDP) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (57448939) PubChem (60098857) PubChem (1158) PubChem (6031) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) PubChem (3084486) PubChem (6101632) PubChem (6604175) PubChem (11811538) PubChem (12049241)
3	C (A)	beta-D-galactopyranose	non-polymer		180.2	1	Chemie (GAL)
4	D (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN) PubChem (27854)
5	E (A)	water	water		18.0	315	Chemie (HOH)

Sequence modifications

A: 64 - 354 (UniProt: H6A2X0)

PDB	External Database	Details
Phe 62	-	expression tag
Met 63	-	expression tag
Arg 176	Gly 176	engineered mutation
Gly 268	Ala 268	engineered mutation
Glu 355	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34371.7
Non-Polymers*	Number of molecules	3
	Total formula weight	639.3
All*	Total formula weight	35010.9

*Water molecules are not included.