4FOD
Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK tyrosine kinase receptor | polymer | 333 | 37568.1 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | A | 4-fluoro-N-{(2E)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2H-benzimidazol-2-ylidene}benzamide | non-polymer | 577.7 | 1 | Chemie (0UV) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A: 1078 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 1097 | Cys 1097 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37568.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 669.8 | |
| All* | Total formula weight | 38238.0 |
