4FOB
Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 353 | 40056.0 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | N-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide | non-polymer | 565.7 | 1 | Chemie (0US) | |||
| 3 | C (A) | water | water | 18.0 | 196 | Chemie (HOH) |
Sequence modifications
A: 1058 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 1097 | Cys 1097 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40056.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 565.7 | |
| All* | Total formula weight | 40621.7 |
