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4FM7

Crystal Structure of BACE with Compound 14g

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Beta-secretase 1polymer40445156.71UniProt (P56817)
Pfam (PF00026)
Homo sapiens (human)Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2
2B
(A)
4-{[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxido-2-thia-1,3,8-triazaspiro[4.5]dec-8-yl]methyl}-2-(propan-2-yloxy)phenolnon-polymer477.61Chemie (0UP)
3C, D
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
4E
(A)
waterwater18.0461Chemie (HOH)
Sequence modifications
A: -3 - 392 (UniProt: P56817)
PDBExternal DatabaseDetails
Arg 393-expression tag
Ser 394-expression tag
His 395-expression tag
His 396-expression tag
His 397-expression tag
His 398-expression tag
His 399-expression tag
His 400-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight45156.7
Non-Polymers*Number of molecules3
Total formula weight608.4
All*Total formula weight45765.1
*Water molecules are not included.

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PDB entries from 2025-07-16

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