4FLL

Human MetAP1 with bengamide analog YZ6, in Mn form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Methionine aminopeptidase 1	polymer	326	36844.9	1	UniProt (P53582) Pfam (PF00557)	Homo sapiens (human)	MAP 1, MetAP 1, Peptidase M 1
2	B, C (A)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D (A)	(E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide	non-polymer		445.5	1	Chemie (YZ6)
4	E (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	F (A)	water	water		18.0	213	Chemie (HOH)

Sequence modifications

A: 90 - 395 (UniProt: P53582)

PDB	External Database	Details
Met 89	-	expression tag
Glu 396	-	expression tag
Phe 397	-	expression tag
Glu 398	-	expression tag
Leu 399	-	expression tag
Val 400	-	expression tag
Asp 401	-	expression tag
Lys 402	-	expression tag
Leu 403	-	expression tag
Ala 404	-	expression tag
Ala 405	-	expression tag
Ala 406	-	expression tag
Leu 407	-	expression tag
Glu 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36844.9
Non-Polymers*	Number of molecules	4
	Total formula weight	578.4
All*	Total formula weight	37423.3

*Water molecules are not included.