4FL8
HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10740.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 (HIV-1) | PR, Retropepsin |
| 2 | C (C) | heptapeptide | polymer | 7 | 801.0 | 1 | UniProt (by SIFTS) (P03367) | Human immunodeficiency virus 1 (HIV-1) | |
| 3 | D (D) | heptapeptide | polymer | 7 | 895.0 | 1 | UniProt (by SIFTS) (P03367) | Human immunodeficiency virus 1 (HIV-1) | |
| 4 | E, F, G, I, J (A, B) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | H, K (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 23177.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 361.5 | |
| All* | Total formula weight | 23538.8 |
