4FFW

Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dipeptidyl peptidase 4	polymer	730	84337.6	2	UniProt (P14740) Pfam (PF18811) Pfam (PF00930) Pfam (PF00326)	Rattus norvegicus (brown rat rat rats)	Bile canaliculus domain-specific membrane glycoprotein, Dipeptidyl peptidase IV, DPP IV, GP110 glycoprotein, T-cell activation antigen CD26, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase 4 60 kDa soluble form, Dipeptidyl peptidase IV 60 kDa soluble form
2	C, F (C, L)	Fab light chain	polymer	210	22895.2	2		Mus musculus (mouse)
3	D, E (D, H)	Fab heavy chain	polymer	217	23307.1	2		Mus musculus (mouse)
4	G, H (A, B)	(2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE	non-polymer		407.3	2	Chemie (715)
5	I, J, K (A, B, C)	water	water		18.0	39	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261079.8
Non-Polymers*	Number of molecules	2
	Total formula weight	814.6
All*	Total formula weight	261894.5

*Water molecules are not included.