4FFW
Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 730 | 84337.6 | 2 | UniProt (P14740) Pfam (PF18811) Pfam (PF00930) Pfam (PF00326) In PDB | Rattus norvegicus (brown rat rat rats) | Bile canaliculus domain-specific membrane glycoprotein, Dipeptidyl peptidase IV, DPP IV, GP110 glycoprotein, T-cell activation antigen CD26, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase 4 60 kDa soluble form, Dipeptidyl peptidase IV 60 kDa soluble form |
2 | C, L | Fab light chain | polymer | 210 | 22895.2 | 2 | Mus musculus (mouse) | ||
3 | D, H | Fab heavy chain | polymer | 217 | 23307.1 | 2 | Mus musculus (mouse) | ||
4 | A, B | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE | non-polymer | 407.3 | 2 | Chemie (715) | |||
5 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 261079.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 814.6 | |
All* | Total formula weight | 261894.5 |