4FEV
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Aminoglycoside 3'-phosphotransferase AphA1-IAB | polymer | 272 | 31022.1 | 6 | UniProt (B0VD92) | Acinetobacter baumannii | |
| 2 | G, J, M, O, T... (A, B, C, D, E...) | KANAMYCIN A | non-polymer | 484.5 | 6 | Chemie (KAN) | |||
| 3 | H, K, N, P, U... (A, B, C, D, E...) | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | non-polymer | 281.4 | 6 | Chemie (PP1) | |||
| 4 | I, L, Q, R, V... (A, B, D, E, F) | SODIUM ION | non-polymer | 23.0 | 7 | Chemie (NA) | |||
| 5 | S (D) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 1404 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 271 (UniProt: B0VD92)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 186132.8 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4815.1 | |
| All* | Total formula weight | 190947.9 |
