4F7I
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus in complex with IPM, Mn and NADH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | 3-isopropylmalate dehydrogenase | polymer | 359 | 38398.9 | 4 | UniProt (Q5SIY4) Pfam (PF00180) In PDB | Thermus thermophilus | 3-IPM-DH, Beta-IPM dehydrogenase, IMDH |
2 | A, C, B, D | 3-ISOPROPYLMALIC ACID | non-polymer | 176.2 | 4 | Chemie (IPM) | |||
3 | A, C, B, D | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
4 | A, C, D | 3[N-MORPHOLINO]PROPANE SULFONIC ACID | non-polymer | 209.3 | 3 | Chemie (MPO) | |||
5 | A, C, B, D | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
6 | D, A, C, B | POTASSIUM ION | non-polymer | 39.1 | 7 | Chemie (K) | |||
7 | B, D, A, C | GLYCEROL | non-polymer | 92.1 | 29 | Chemie (GOL) | |||
8 | B, D, A, C | ETHANOL | non-polymer | 46.1 | 6 | Chemie (EOH) | |||
9 | water | water | 18.0 | 440 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 345 (UniProt: Q5SIY4)
PDB | External Database | Details |
---|---|---|
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 346 | - | expression tag |
Ala 347 | - | expression tag |
Ala 348 | - | expression tag |
Leu 349 | - | expression tag |
Glu 350 | - | expression tag |
His 351 | - | expression tag |
His 352 | - | expression tag |
His 353 | - | expression tag |
His 354 | - | expression tag |
His 355 | - | expression tag |
His 356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 153595.5 | |
Non-Polymers* | Number of molecules | 57 |
Total formula weight | 7426.7 | |
All* | Total formula weight | 161022.3 |