4F5R
Open and closed ternary complex of R283K DNA polymerase beta with a dCTP analog in the same asymmetric unit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA polymerase beta | polymer | 335 | 38213.7 | 2 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (human) | |
| 2 | C, F (D, C) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 2 | synthetic construct | ||
| 3 | D, G (P, G) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3') | polymer | 10 | 3061.0 | 2 | synthetic construct | ||
| 4 | E, H (T, F) | DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4869.2 | 2 | synthetic construct | ||
| 5 | I, M, Q, R (A, B, T, G) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 6 | J, N (A, B) | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine | non-polymer | 501.2 | 2 | Chemie (6CF) | |||
| 7 | K, L, O, P (B, D, T) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 8 | S, T, U, V, W... (A, B, D, P, T...) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Lys 283 | Arg 283 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 95359.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1314.0 | |
| All* | Total formula weight | 96673.7 |
