4F5B
Triple mutant Src SH2 domain bound to phosphotyrosine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase Src | polymer | 112 | 12699.3 | 1 | UniProt (P12931) Pfam (PF00017) | Homo sapiens (human) | Proto-oncogene c-Src, pp60c-src, p60-Src |
| 2 | B (A) | O-PHOSPHOTYROSINE | non-polymer | 261.2 | 1 | Chemie (PTR) | |||
| 3 | C (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 144 - 252 (UniProt: P12931)
| PDB | External Database | Details |
|---|---|---|
| Gly 141 | - | expression tag |
| Ala 142 | - | expression tag |
| Met 143 | - | expression tag |
| Val 183 | Thr 183 | engineered mutation |
| Ala 188 | Cys 188 | engineered mutation |
| Leu 206 | Lys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12699.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 261.2 | |
| All* | Total formula weight | 12960.5 |
