4F46
Crystal structure of wild type human CD38 in complex with NAADP and ADPRP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ADP-ribosyl cyclase 1 | polymer | 257 | 29812.7 | 2 | UniProt (P28907) Pfam (PF02267) In PDB | Homo sapiens (human) | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10 |
2 | A | [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5S)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | non-polymer | 639.3 | 1 | Chemie (DVN) | |||
3 | B | [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate | non-polymer | 744.4 | 1 | Chemie (DN4) | |||
4 | water | water | 18.0 | 392 | Chemie (HOH) |
Sequence modifications
A, B: 46 - 300 (UniProt: P28907)
PDB | External Database | Details |
---|---|---|
Glu 44 | - | expression tag |
Phe 45 | - | expression tag |
Thr 49 | Gln 49 | engineered mutation |
Asp 100 | Asn 100 | engineered mutation |
Asp 164 | Asn 164 | engineered mutation |
Asp 209 | Asn 209 | engineered mutation |
Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 59625.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1383.7 | |
All* | Total formula weight | 61009.2 |