4F37

Structure of the tethered N-terminus of Alzheimer's disease A peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Colicin-E7 immunity protein	polymer	124	14154.2	2	UniProt (Q03708) Pfam (PF01320)	Escherichia coli	ImmE7, Microcin-E7 immunity protein
2	C, D (F, H)	Im7 immunity protein	polymer	228	24841.8	2	Pfam (PF07654) UniProt (by SIFTS) (P01863)	Mus musculus (mouse)
3	E, F (K, L)	Fab WO2 anti-amyloid-beta antibody Fab fragment	polymer	219	24193.9	2	Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (A2NHM3)	Mus musculus (mouse)
4	G, H, I, J, K... (A, B, F, H, K...)	water	water		18.0	265	Chemie (HOH)

Sequence modifications

A, B: 18 - 103 (UniProt: Q03708)

PDB	External Database	Details
Asp 1	-	expression tag
Ala 2	-	expression tag
Glu 3	-	expression tag
Phe 4	-	expression tag
Arg 5	-	expression tag
His 6	-	expression tag
Asp 7	-	expression tag
Ser 8	-	expression tag
Gly 9	-	expression tag
Tyr 10	-	expression tag
Glu 11	-	expression tag
Val 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
Gln 15	-	expression tag
Lys 16	-	expression tag
Ser 17	-	expression tag
Ala 104	-	expression tag
Ala 105	-	expression tag
Ala 106	-	expression tag
Asp 107	-	expression tag
Tyr 108	-	expression tag
Lys 109	-	expression tag
Asp 110	-	expression tag
Asp 111	-	expression tag
Asp 112	-	expression tag
Asp 113	-	expression tag
Lys 114	-	expression tag
Ala 115	-	expression tag
Ala 116	-	expression tag
Asp 117	-	expression tag
Tyr 118	-	expression tag
Lys 119	-	expression tag
Asp 120	-	expression tag
Asp 121	-	expression tag
Asp 122	-	expression tag
Asp 123	-	expression tag
Lys 124	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	126379.8
All*	Total formula weight	126379.8

*Water molecules are not included.