4F1T
Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase roco4 | polymer | 287 | 32616.5 | 1 | UniProt (Q6XHB2) Pfam (PF07714) | Dictyostelium discoideum (Slime mold) | Ras of complex proteins and C-terminal of roc 4 |
| 2 | B, C (A) | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE | non-polymer | 319.4 | 2 | Chemie (H52) | |||
| 3 | D (A) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A: 1019 - 1292 (UniProt: Q6XHB2)
| PDB | External Database | Details |
|---|---|---|
| Gly 1006 | - | expression tag |
| Ala 1007 | - | expression tag |
| Met 1008 | - | expression tag |
| Gly 1009 | - | expression tag |
| Gly 1010 | - | expression tag |
| Ser 1011 | - | expression tag |
| Glu 1012 | - | expression tag |
| Phe 1013 | - | expression tag |
| Pro 1014 | - | expression tag |
| Lys 1015 | - | expression tag |
| Ser 1016 | - | expression tag |
| Arg 1017 | - | expression tag |
| Leu 1018 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32616.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 638.8 | |
| All* | Total formula weight | 33255.4 |
