4EY5
Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-huperzine A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Acetylcholinesterase | polymer | 542 | 59447.1 | 2 | UniProt (P22303) Pfam (PF00135) | Homo sapiens (human) | AChE |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 3 | E, J (A, B) | Huperzine A | non-polymer | 242.3 | 2 | Chemie (HUP) PubChem (1253) PubChem (449069) PubChem (854026) PubChem (907504) PubChem (4369233) PubChem (5353252) PubChem (5558179) PubChem (5912039) PubChem (6348872) PubChem (9794806) PubChem (16757915) PubChem (25200044) PubChem (44461111) PubChem (44826349) PubChem (1633595) PubChem (98043106) PubChem (6565233) PubChem (59922556) PubChem (71308731) PubChem (89451773) PubChem (118215897) PubChem (173587594) | |||
| 4 | F, K (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) PubChem (679) | |||
| 5 | G, H, L (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | I (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | M, N (B) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) PubChem (943) | |||
| 8 | O, P (A, B) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118894.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1141.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1172.3 | |
| All* | Total formula weight | 121207.6 |
