4EW2
The structure of human glycinamide ribonucleotide transformylase in complex with 10S-methylthio-DDATHF.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Trifunctional purine biosynthetic protein adenosine-3 | polymer | 209 | 22678.9 | 1 | UniProt (P22102) Pfam (PF00551) | Homo sapiens (human) | Phosphoribosylamine--glycine ligase, Glycinamide ribonucleotide synthetase, GARS, Phosphoribosylglycinamide synthetase, Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase, Phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase, GAR transformylase, GART |
| 2 | B (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | N-({4-[(1S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid | non-polymer | 477.5 | 1 | Chemie (DXY) | |||
| 5 | F (A) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 1 - 203 (UniProt: P22102)
| PDB | External Database | Details |
|---|---|---|
| His 204 | - | expression tag |
| His 205 | - | expression tag |
| His 206 | - | expression tag |
| His 207 | - | expression tag |
| His 208 | - | expression tag |
| His 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22678.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 764.6 | |
| All* | Total formula weight | 23443.6 |
