4ER0
Crystal Structure of human DOT1L in complex with inhibitor FED1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 421 | 47980.7 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | B (A) | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5'-deoxyadenosine | non-polymer | 540.7 | 1 | Chemie (AW1) | |||
| 3 | C, D, E (A) | UNKNOWN ATOM OR ION | non-polymer | 3 | Chemie (UNX) | ||||
| 4 | F (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 1 - 420 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47980.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 540.7 | |
| All* | Total formula weight | 48521.3 |
