4EPY
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GTPase KRas | polymer | 170 | 19354.8 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (human) | K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed |
| 2 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | N-[2-(1H-indol-3-ylmethyl)-1H-benzimidazol-5-yl]-L-prolinamide | non-polymer | 359.4 | 1 | Chemie (0QY) | |||
| 5 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19354.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 826.9 | |
| All* | Total formula weight | 20181.8 |
