4EP2
Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate RT-RH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | protease, tethered dimer | polymer | 203 | 22005.0 | 1 | UniProt (P03369) Pfam (PF00077) In PDB | HIV-1 M:B_ARV2/SF2 (HIV-1) | |
| 2 | B | substrate RT-RH | polymer | 8 | 900.9 | 1 | UniProt (Q9YV20) In PDB | Human immunodeficiency virus 1 | |
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: P03369)
A: 101 - 199 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Asn 25 | Asp 515 | engineered mutation |
| Leu 67 | Cys 557 | engineered mutation |
| Met 95 | Cys 585 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 99 | - | linker |
| Gly 99 | - | linker |
| Ser 99 | - | linker |
| Ser 99 | - | linker |
| Gly 99 | - | linker |
| Lys 107 | Gln 497 | engineered mutation |
| Asn 125 | Asp 515 | engineered mutation |
| Leu 167 | Cys 557 | engineered mutation |
| Met 195 | Cys 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22905.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 187.1 | |
| All* | Total formula weight | 23093.0 |
