4EOZ

Crystal structure of the SPOP BTB domain complexed with the Cul3 N-terminal domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Speckle-type POZ protein	polymer	145	16167.5	2	UniProt (O43791) Pfam (PF00651) In PDB	Homo sapiens (human)	HIB homolog 1, Roadkill homolog 1
2	B, D	Cullin-3	polymer	364	43461.7	2	UniProt (Q13618) Pfam (PF00888) In PDB	Homo sapiens (human)	CUL-3
3		water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, C: 177 - 319 (UniProt: O43791)

PDB	External Database	Details
Gly 175	-	EXPRESSION TAG
Ser 176	-	EXPRESSION TAG

B, D: 20 - 381 (UniProt: Q13618)

PDB	External Database	Details
Gly 18	-	EXPRESSION TAG
Ser 19	-	EXPRESSION TAG
Arg 342	Ile 342	ENGINEERED MUTATION
Asp 346	Leu 346	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	119258.5
All*	Total formula weight	119258.5

*Water molecules are not included.