4EOS
Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 2 | polymer | 300 | 34184.6 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2, p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | Cyclin-A |
| 3 | E, F (A, C) | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one | non-polymer | 351.4 | 2 | Chemie (1RO) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 297 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127617.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 702.9 | |
| All* | Total formula weight | 128320.6 |
