4EKI
Crystal Structure of DOT1L in complex with EPZ004777
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 425 | 48566.2 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | B (A) | 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine | non-polymer | 539.7 | 1 | Chemie (0QK) PubChem (56962336) PubChem (89911625) PubChem (121405800) PubChem (173939491) PubChem (67811139) PubChem (70702060) PubChem (76450046) PubChem (86765433) PubChem (90367749) PubChem (118425046) PubChem (118885623) PubChem (124080926) PubChem (124224096) PubChem (124224097) PubChem (124224098) PubChem (125113119) PubChem (132070303) PubChem (134695328) PubChem (138107147) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 1 - 416 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48566.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 827.9 | |
| All* | Total formula weight | 49394.1 |
