4EHA
Allosteric Modulation of Caspase-3 through Mutagenesis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Caspase-3 | polymer | 277 | 31691.0 | 2 | UniProt (P42574) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12 |
| 2 | F, B | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | polymer | 6 | 534.9 | 2 | BIRD (PRD_000238) | ||
| 3 | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 277 (UniProt: P42574)
| PDB | External Database | Details |
|---|---|---|
| His 266 | Val 266 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64451.8 | |
| All* | Total formula weight | 64451.8 |
