4ECS

Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 80 sec

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA polymerase eta	polymer	435	48617.7	1	UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) In PDB	Homo sapiens (human)	RAD30 homolog A, Xeroderma pigmentosum variant type protein
2	T	DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3')	polymer	12	3637.4	1
3	P	DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3')	polymer	9	2739.8	1
4	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7	P	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	1	Chemie (DTP)
8	P	DIPHOSPHATE	non-polymer		173.9	1	Chemie (DPO)
9		water	water		18.0	308	Chemie (HOH)

Sequence modifications

A: 1 - 432 (UniProt: Q9Y253)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	54994.9
Non-Polymers*	Number of molecules	7
	Total formula weight	938.0
All*	Total formula weight	55932.9

*Water molecules are not included.